Author's response to reviews Title: The TGFBR1*6A allele is not associated with susceptibility to colorectal cancer in a Spanish population: a case-control study Authors:
نویسندگان
چکیده
Adela Castillejo ([email protected]) Trinidad Mata-Balaguer ([email protected]) Paola Montenegro ([email protected]) Enrique Ochoa ([email protected]) Rafael Lázaro ([email protected]) Ana Martínez-Cantó ([email protected]) María I Castillejo ([email protected]) Carla Guarinos ([email protected]) Víctor M Barberá ([email protected]) Carmen Guillén-Ponce ([email protected]) Alfredo Carrato ([email protected]) José L Soto ([email protected])
منابع مشابه
Lack of an association between the TGFBR1*6A variant and colorectal cancer risk.
PURPOSE Recently a common variant of the TGFBR1 gene, TGFBR1*6A, has been proposed to act as a low-penetrance tumor susceptibility allele for colorectal cancer, but data from published studies with individually low statistical power are conflicting. To further evaluate the relationship between TGFBR1*6A and colorectal cancer risk, we have conducted a large case-control study and a meta-analysis...
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Our analysis definitely excludes the possibility of the TGFBR1*6A allele increasing the risk of colorectal neoplasia in our sample population. A recent study validating linkage of colorectal cancer to chromosome 9q also excluded the TGFBR1*6A allele as a disease-causing variant in that sample. We conclude that there remains an unidentified susceptibility locus in the region 9q22.2-31.2.
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BACKGROUND Numerous epidemiological studies have evaluated the association between TGFBR1 polymorphisms and the risk of cancer, however, the results remain inconclusive. To derive a more precise estimation of the relation, we conducted a comprehensive meta-analysis of all available case-control studies relating the TGFBR1*6A and IVS7+24G>A polymorphisms of the TGFBR1 gene to the risk of cancer....
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Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide, and its occurrence can be ascribed to genetic susceptibility. Mitochondrial DNA 4977-bp (mtDNA 4977), as the most described mtDNA deletion, has been long proposed to be involved in various types of cancers. However, a few studies on mtDNA 4977-bp deletion in Iranian patients with CRC have been reported. The cu...
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